USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P54819 USC-OGP 2-DE database:  P54819 P54819 General information about the entry View entry in simple text format Entry name KAD2_HUMAN Primary accession number P54819 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Adenylate kinase 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03168}; Short=AK 2 {ECO:0000255|HAMAP-Rule:MF_03168}; EC=2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_03168}; AltName: Full=ATP-AMP transphosphorylase 2 {ECO:0000255|HAMAP-Rule:MF_03168}; AltName: Full=ATP:AMP phosphotransferase {ECO:0000255|HAMAP-Rule:MF_03168}; AltName: Full=Adenylate monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_03168}; Contains: RecName: Full=Adenylate kinase 2, mitochondrial, N-terminally processed {ECO:0000255|HAMAP-Rule:MF_03168};. Gene name Name=AK2 {ECO:0000255|HAMAP-Rule:MF_03168} Synonyms=ADK2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1009: pI=7.62; Mw=27000 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1272: pI=7.85; Mw=27912 Cross-references UniProtKB/Swiss-Prot P54819; KAD2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KAD2_HUMAN Primary accession number P54819 Secondary accession number(s) A8K6L1 B4DHH7 B4DL64 Q16856 Q5EB54 Q5TIF7 Q8TCY2 Q8TCY3 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 178) Name and origin of the protein Description RecName: Full=Adenylate kinase 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03168}; Short=AK 2 {ECO:0000255|HAMAP-Rule:MF_03168}; EC=2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_03168}; AltName: Full=ATP-AMP transphosphorylase 2 {ECO:0000255|HAMAP-Rule:MF_03168}; AltName: Full=ATP:AMP phosphotransferase {ECO:0000255|HAMAP-Rule:MF_03168}; AltName: Full=Adenylate monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_03168}; Contains: RecName: Full=Adenylate kinase 2, mitochondrial, N-terminally processed {ECO:0000255|HAMAP-Rule:MF_03168}; Gene name Name=AK2 {ECO:0000255|HAMAP-Rule:MF_03168} Synonyms=ADK2 Encoded on Name=AK2 {ECO:0000255|HAMAP-Rule:MF_03168}; Synonyms=ADK2 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U39945; AAC52061.1; -; mRNA EMBL U84371; AAB41790.1; -; mRNA EMBL U54645; AAC13881.1; -; mRNA EMBL AB005621; BAC16747.1; -; mRNA EMBL AB005622; BAC16748.1; -; mRNA EMBL AY080899; AAL87027.1; -; mRNA EMBL AY080900; AAL87028.1; -; mRNA EMBL AK291676; BAF84365.1; -; mRNA EMBL AK295105; BAG58139.1; -; mRNA EMBL AK296863; BAG59426.1; -; mRNA EMBL AB451267; BAG70081.1; -; mRNA EMBL AB451394; BAG70208.1; -; mRNA EMBL AL020995; CAI19351.1; -; Genomic_DNA EMBL AL020995; CAI19352.1; -; Genomic_DNA EMBL CH471059; EAX07484.1; -; Genomic_DNA EMBL CH471059; EAX07486.1; -; Genomic_DNA EMBL BC009405; AAH09405.1; -; mRNA EMBL BC070127; AAH70127.1; -; mRNA EMBL BC090040; AAH90040.1; -; mRNA CCDS CCDS373.1; -. [P54819-2]; . CCDS CCDS374.1; -. [P54819-1]; . PIR G02248; G02248; . PIR JC5893; JC5893; . RefSeq NP_001186128.1; NM_001199199.1. [P54819-5]; . RefSeq NP_001306068.1; NM_001319139.1; . RefSeq NP_001306069.1; NM_001319140.1. [P54819-6]; . RefSeq NP_001616.1; NM_001625.3. [P54819-1]; . RefSeq NP_037543.1; NM_013411.4. [P54819-2]; . UniGene Hs.470907; -; . PDB 2C9Y; X-ray; 2.10 A; A=1-239 PDBsum 2C9Y; -; . ProteinModelPortal P54819; -; . SMR P54819; -; . BioGrid 106707; 39; . IntAct P54819; 12; . STRING 9606.ENSP00000346921; -; . BindingDB P54819; -; . ChEMBL CHEMBL4938; -; . DrugBank DB00718; Adefovir Dipivoxil; . DrugBank DB01717; Bis(Adenosine)-5'-Pentaphosphate; . DrugBank DB00300; Tenofovir; . iPTMnet P54819; -; . PhosphoSitePlus P54819; -; . SwissPalm P54819; -; . BioMuta AK2; -; . DMDM 1708596; -; . OGP P54819; -; . REPRODUCTION-2DPAGE IPI00218988; -; . UCD-2DPAGE P54819; -; . EPD P54819; -; . MaxQB P54819; -; . PaxDb P54819; -; . PeptideAtlas P54819; -; . PRIDE P54819; -; . DNASU 204; -; . Ensembl ENST00000354858; ENSP00000346921; ENSG00000004455. [P54819-1]; . Ensembl ENST00000373449; ENSP00000362548; ENSG00000004455. [P54819-2]; . GeneID 204; -; . KEGG hsa:204; -; . UCSC uc001bwo.3; human. [P54819-1]; . CTD 204; -; . DisGeNET 204; -; . GeneCards AK2; -; . HGNC HGNC:362; AK2; . HPA HPA018479; -; . MalaCards AK2; -; . MIM 103020; gene; . MIM 267500; phenotype; . neXtProt NX_P54819; -; . OpenTargets ENSG00000004455; -; . Orphanet 33355; Reticular dysgenesis; . PharmGKB PA24656; -; . eggNOG KOG3078; Eukaryota; . eggNOG COG0563; LUCA; . GeneTree ENSGT00830000128340; -; . HOVERGEN HBG000458; -; . InParanoid P54819; -; . KO K00939; -; . OMA CPKGIRA; -; . OrthoDB EOG091G06BH; -; . PhylomeDB P54819; -; . TreeFam TF300896; -; . Reactome R-HSA-499943; Synthesis and interconversion of nucleotide di- and triphosphates; . EvolutionaryTrace P54819; -; . GeneWiki AK2; -; . GenomeRNAi 204; -; . PRO PR:P54819; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000004455; -; . CleanEx HS_AK2; -; . ExpressionAtlas P54819; baseline and differential; . Genevisible P54819; HS; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl; . GO GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome; . GO GO:0097226; C:sperm mitochondrial sheath; IEA:Ensembl; . GO GO:0004017; F:adenylate kinase activity; EXP:Reactome; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0006172; P:ADP biosynthetic process; IEA:InterPro; . GO GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome; . CDD cd01428; ADK; 1; . Gene3D 3.40.50.300; -; 1; . HAMAP MF_00235; Adenylate_kinase_Adk; 1; . HAMAP MF_03168; Adenylate_kinase_AK2; 1; . InterPro IPR006259; Adenyl_kin_sub; . InterPro IPR000850; Adenylat/UMP-CMP_kin; . InterPro IPR033690; Adenylat_kinase_CS; . InterPro IPR007862; Adenylate_kinase_lid-dom; . InterPro IPR028587; AK2; . InterPro IPR027417; P-loop_NTPase; . PANTHER PTHR23359; PTHR23359; 1; . Pfam PF05191; ADK_lid; 1; . PRINTS PR00094; ADENYLTKNASE; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01351; adk; 1; . PROSITE PS00113; ADENYLATE_KINASE; 1; .

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